CrossFire user here.
Upon release of 12.4 Catalyst with CAP1,
http://twitter.com/#!/catalystcreator says
"Note - TERA will not have a CF profile - the developer was not willing to modify the application to make it CF compatible"
I too had been anticipating a CAP for Tera based on the informal Feb 16 notice "CAP for TERA will be coming" but apparently plans have changed.
In Catalyst Control Center I defined an application profile for TERA.exe and I've been using "AFR Friendly" mode because "Default Mode" didn't show a CF performance increase. I haven't measured but the difference was palpable even at the Character Select screen. Using "AFR Friendly" has given me two noticeable problems:
Shading/shadows flicker every alternate frame. This problem seems to go away for a while if I open the Video Options menu in-game and use preset 1 for a moment, then turn it back up to 5 (where I like to play). It re-appears whenever you teleport, Alt-tab, or otherwise reinitialize things. The problem tends to diminish on its own after a couple of minutes, so I'm not sure if twiddling the Preset setting does anything or if that's a superstitious habit I've now picked up, but I often do it anyway.
The name labels likewise flicker (one frame on, one frame off, give or take) and occasionally display garbage. I have gotten used to it, but for a while I had the name labels disabled because it annoyed me at the time.
I am also using EyeFinity across 3 displays but I'm guessing these artifacts come from CF and not EyeFinity.